Five clinical panels
The Genomatik report is organized into five distinct sections, each built on public, verifiable scientific databases. Not an accumulation of data: a structure designed to be read, understood, and used over time.
1. Genetic predispositions
27 conditions analyzed across cardiovascular, metabolic, neurodegenerative, and oncological areas.
For each condition: genetic variant (rs-ID), relative risk (odds ratio), confidence interval, and GWAS reference.
Only associations with p-value below 5×10⁻⁸, replicated on independent cohorts.
Examples: type 2 diabetes, coronary artery disease, hypertension, Alzheimer's, Parkinson's, celiac disease, rheumatoid arthritis, melanoma, prostate cancer, osteoporosis, asthma, psoriasis, Crohn's and others.
2. CPIC Pharmacogenomics
9 genes · 45 active ingredients with CPIC Level A recommendations.
Pharmacogenomics is the area where genetic data becomes most concretely actionable.
CYP2C19
Clopidogrel, escitalopram, sertraline, citalopram, omeprazole, lansoprazole, voriconazole, amitriptyline.
CYP2D6
Codeine, tramadol, amitriptyline, nortriptyline, ondansetron, tamoxifen, atomoxetine, venlafaxine.
SLCO1B1
Simvastatin, atorvastatin, rosuvastatin, pravastatin and other statins.
DPYD
Fluorouracil, capecitabine. DPYD variants can cause severe toxicity.
VKORC1 + CYP2C9
Warfarin. The VKORC1 + CYP2C9 combination influences optimal dose.
HLA-B
Carbamazepine, oxcarbazepine, phenytoin, allopurinol, abacavir.
TPMT / NUDT15
Azathioprine, mercaptopurine, thioguanine. Risk of severe myelosuppression.
CYP3A5
Tacrolimus. Initial dosage based on CYP3A5 genotype.
All recommendations follow CPIC Level A guidelines — the highest evidence grade.
3. Phenotypic traits
84 traits analyzed with verifiable scientific documentation.
Phenotypic traits extend the genetic profile beyond the strictly clinical area.
Examples: lactose intolerance (LCT), caffeine sensitivity (CYP1A2), alcohol metabolism (ALDH2), muscle fiber type (ACTN3), bitter taste (TAS2R38), chronobiology, baldness and many more.
4. Carrier Status
22 autosomal recessive conditions analyzed for carrier status.
Carrier status identifies whether a person is a healthy carrier of a recessive variant.
Particularly relevant for couples planning a pregnancy.
Conditions: cystic fibrosis (CFTR), beta-thalassemia, sickle cell anemia, SMA (SMN1), phenylketonuria (PAH), congenital deafness (GJB2), hemochromatosis (HFE) and others.
5. Wellness Rating
Algorithmic score calculated on the ratio between favorable and total variants.
Qualitative assessment of the overall genetic profile, not a diagnosis.
Unlike services with opaque algorithms, the Wellness Rating declares its calculation method.